Objective: Some of the factors affecting serum osmolality are also known risk factors for coronary artery disease. In the present study, we aimed to investigate if there is a relationship between serum osmolality and a history of coronary artery disease.

Methods: The present study was designed as a case control study. We selected 141 patients aged 45 years or over with consecutive sampling method. Of these, 61 patients had a history of coronary artery disease. In the study group, coronary artery disease was documented and the patients have been under medication for this specific illness. Serum osmolality was calculated using appropriate formula.

Results: Estimated serum osmolality (t= -4.209, p=0.000), fasting plasma glucose (t= -2,606, p = 0.01) and waist to hip ratio (t= -2,193, p=0.03) were higher in patients with coronary artery disease.

Conclusion: We have shown that estimated serum osmolality correlates with a history of coronary artery disease.

Keywords: BUN, coronary artery disease, glucose, osmolality, sodium