Warfarin is an oral anticoagulant, can lead to skin necrosis quite rarely that is a serious complication. However this complication is observed usually during the first 10 days of treatment, the presented case, as a result of inappropriate drug withdrawal and restarting, has emerged after two years from the start of treatment as late onset. After stopping the warfarin therapy , the patient was treated with oral acetylsalicylic acid and skin necrosis regressed within days without recurrence. In the treatment of this complication, parenterally and the new oral anticoagulant agents are the other treatment options.