Tobacco is the leading cause of preventable premature death and disabilities in the world. Current cessation medications include nicotine replacement therapy (NRT), varenicline, and bupropion. Bupropion is used for smoking cessation therapy as well as depression treatment. Bupropion HCL is an antidepresant that acts as a norepinephrine and dopamine reuptake inhibitor and has a favorable side-effect profile. Many drugs may cause skin reactions. Dermatologic adverse effects have increased because use of antidepressant drugs all over the world. The most common side-effects of Bupropion HCL include insomnia, constipation, headache and dry mouth. Unlike these side-effects, we present a case of serum sickness-like reaction due to sustained-release bupropion SR during smoking cessation therapy in this case report.

Keywords: Bupropion SR, serum sickness-like reaction, side-effect